@article{Wang_Qi_Yu_Jia_Cheng_Zheng_Wu_Bao_Wang_Zhao_Cui_Zheng_2019, title={Revealing the Intrinsic Peroxidase-Like Catalytic Mechanism of Heterogeneous Single-Atom Co–MoS2}, volume={11}, url={https://www.nmlett.org/index.php/nml/article/view/135}, DOI={10.1007/s40820-019-0324-7}, abstractNote={<p>The single-atom nanozyme is a new concept and has tremendous prospects to become a next-generation nanozyme. However, few studies have been carried out to elucidate the intrinsic mechanisms for both the single atoms and the supports in single-atom nanozymes. Herein, the heterogeneous single-atom Co–MoS<sub>2</sub> (SA Co–MoS<sub>2</sub>) is demonstrated to have excellent potential as a high-performance peroxidase mimic. Because of the well-defined structure of SA Co–MoS<sub>2</sub>, its peroxidase-like mechanism is extensively interpreted through experimental and theoretical studies. Due to the different adsorption energies of substrates on different parts of SA Co–MoS<sub>2</sub> in the peroxidase-like reaction, SA Co favors electron transfer mechanisms, while MoS<sub>2</sub> relies on Fenton-like reactions. The different catalytic pathways provide an intrinsic understanding of the remarkable performance of SA Co–MoS<sub>2</sub>. The present study not only develops a new kind of single-atom catalyst (SAC) as an elegant platform for understanding the enzyme-like activities of heterogeneous nanomaterials but also facilitates the novel application of SACs in biocatalysis.</p> <p>Highlights:</p> <p>1 Single-atom Co–MoS<sub>2</sub> (SA Co–MoS<sub>2</sub>) is prepared successfully to serve as a proof-of-concept nanozyme model, which exhibits peroxidase-like performance comparable to that of natural enzymes.<br>2 The different mechanisms between the single-atom metal center and the support are investigated experimentally and theoretically.</p>}, journal={Nano-Micro Letters}, author={Wang, Ying and Qi, Kun and Yu, Shansheng and Jia, Guangri and Cheng, Zhiliang and Zheng, Lirong and Wu, Qiong and Bao, Qiaoliang and Wang, Qingqing and Zhao, Jingxiang and Cui, Xiaoqiang and Zheng, Weitao}, year={2019}, month={Nov.}, pages={102} }