@article{Chen_Zhang_Huang_Wan_Li_Fan_Luo_Wang_Zhu_Wang_2019, title={Antiangiogenesis-Combined Photothermal Therapy in the Second Near-Infrared Window at Laser Powers Below the Skin Tolerance Threshold}, volume={11}, url={https://www.nmlett.org/index.php/nml/article/view/144}, DOI={10.1007/s40820-019-0327-4}, abstractNote={<p>Photothermal agents with strong light absorption in the second near-infrared (NIR-II) region (1000–1350&nbsp;nm) are strongly desired for successful photothermal therapy (PTT). In this work, titania-coated Au nanobipyramids (NBP@TiO<sub>2</sub>) with a strong plasmon resonance in the NIR-II window were synthesized. The NBP@TiO<sub>2</sub> nanostructures have a high photothermal conversion efficiency of (93.3 ± 5.2)% under 1064-nm laser irradiation. They are also capable for loading an anticancer drug combretastatin A-4 phosphate (CA4P). In vitro PTT studies reveal that 1064-nm laser irradiation can efficiently ablate human lung cancer A549 cells and enhance the anticancer effect of CA4P. Moreover, the CA4P-loaded NBP@TiO<sub>2</sub> nanostructures combined with PTT induce a synergistic antiangiogenesis effect. In vivo studies show that such CA4P-loaded NBP@TiO<sub>2</sub> nanostructures under mild 1064-nm laser irradiation at an optical power density of 0.4&nbsp;W&nbsp;cm<sup>−2</sup>, which is lower than the skin tolerance threshold value, exhibit a superior antitumor effect. This work presents not only the development of the NBP@TiO<sub>2</sub> nanostructures as a novel photothermal agent responsive in the NIR-II window but also a unique combined chemo-photothermal therapy strategy for cancer therapy.</p> <p>Highlights:</p> <p>1 Titania-coated Au nanobipyramids (NBP@TiO<sub>2</sub>) with a high photothermal conversion efficiency in the NIR-II window are synthesized.<br>2 The TiO<sub>2</sub> shell is capable for the loading of the anticancer drug combretastatin A-4 phosphate (CA4P).<br>3 The CA4P-loaded NBP@TiO<sub>2</sub> nanostructures subjected with photothermal therapy induce synergistic anticancer and antiangiogenesis effects under 1064-nm laser irradiation at a power density lower than the skin tolerance threshold value.</p>}, journal={Nano-Micro Letters}, author={Chen, Jian‑Li and Zhang, Han and Huang, Xue‑Qin and Wan, Hong‑Ye and Li, Jie and Fan, Xing‑Xing and Luo, Kathy Qian and Wang, Jinhua and Zhu, Xiao‑Ming and Wang, Jianfang}, year={2019}, month={Oct.}, pages={93} }