@article{Xu_Mo_Xie_Hu_2021, title={In-Cell Nanoelectronics: Opening the Door to Intracellular Electrophysiology}, volume={13}, url={https://www.nmlett.org/index.php/nml/article/view/893}, DOI={10.1007/s40820-021-00655-x}, abstractNote={<p>Establishing a reliable electrophysiological recording platform is crucial for cardiology and neuroscience research. Noninvasive and label-free planar multitransistors and multielectrode arrays are conducive to perform the large-scale cellular electrical activity recordings, but the signal attenuation limits these extracellular devices to record subthreshold activities. In recent decade, in-cell nanoelectronics have been rapidly developed to open the door to intracellular electrophysiology. With the unique three-dimensional nanotopography and advanced penetration strategies, high-throughput and high-fidelity action potential like signal recordings is expected to be realized. This review summarizes in-cell nanoelectronics from versatile nano-biointerfaces, penetration strategies, active/passive nanodevices, systematically analyses the applications in electrogenic cells and especially evaluates the influence of nanodevices on the high-quality intracellular electrophysiological signals. Further, the opportunities, challenges and broad prospects of in-cell nanoelectronics are prospected, expecting to promote the development of in-cell electrophysiological platforms to meet the demand of theoretical investigation and clinical application.</p> <p>Highlights:</p> <p>1 The factors affecting in-cell nanoelectronics for electrophysiology recording were discussed from versatile nano-biointerfaces, penetration strategies, active and passive nanodevices.<br>2 The applications of in-cell nanodevices in cardiomyocyte and neuron were further reviewed and evaluated.<br>3 The current challenges of nanodevices for intracellular electrophysiology and their potential applications in biomedical fields were discussed.</p>}, journal={Nano-Micro Letters}, author={Xu, Dongxin and Mo, Jingshan and Xie, Xi and Hu, Ning}, year={2021}, month={May}, pages={127} }