TY - JOUR AU - Chen, Jian‑Li AU - Zhang, Han AU - Huang, Xue‑Qin AU - Wan, Hong‑Ye AU - Li, Jie AU - Fan, Xing‑Xing AU - Luo, Kathy Qian AU - Wang, Jinhua AU - Zhu, Xiao‑Ming AU - Wang, Jianfang PY - 2019/10/31 Y2 - 2024/03/28 TI - Antiangiogenesis-Combined Photothermal Therapy in the Second Near-Infrared Window at Laser Powers Below the Skin Tolerance Threshold JF - Nano-Micro Letters JA - Nano-Micro Lett VL - 11 IS - SE - Articles DO - 10.1007/s40820-019-0327-4 UR - https://www.nmlett.org/index.php/nml/article/view/144 SP - 93 AB - <p>Photothermal agents with strong light absorption in the second near-infrared (NIR-II) region (1000–1350&nbsp;nm) are strongly desired for successful photothermal therapy (PTT). In this work, titania-coated Au nanobipyramids (NBP@TiO<sub>2</sub>) with a strong plasmon resonance in the NIR-II window were synthesized. The NBP@TiO<sub>2</sub> nanostructures have a high photothermal conversion efficiency of (93.3 ± 5.2)% under 1064-nm laser irradiation. They are also capable for loading an anticancer drug combretastatin A-4 phosphate (CA4P). In vitro PTT studies reveal that 1064-nm laser irradiation can efficiently ablate human lung cancer A549 cells and enhance the anticancer effect of CA4P. Moreover, the CA4P-loaded NBP@TiO<sub>2</sub> nanostructures combined with PTT induce a synergistic antiangiogenesis effect. In vivo studies show that such CA4P-loaded NBP@TiO<sub>2</sub> nanostructures under mild 1064-nm laser irradiation at an optical power density of 0.4&nbsp;W&nbsp;cm<sup>−2</sup>, which is lower than the skin tolerance threshold value, exhibit a superior antitumor effect. This work presents not only the development of the NBP@TiO<sub>2</sub> nanostructures as a novel photothermal agent responsive in the NIR-II window but also a unique combined chemo-photothermal therapy strategy for cancer therapy.</p><p>Highlights:</p><p>1 Titania-coated Au nanobipyramids (NBP@TiO<sub>2</sub>) with a high photothermal conversion efficiency in the NIR-II window are synthesized.<br>2 The TiO<sub>2</sub> shell is capable for the loading of the anticancer drug combretastatin A-4 phosphate (CA4P).<br>3 The CA4P-loaded NBP@TiO<sub>2</sub> nanostructures subjected with photothermal therapy induce synergistic anticancer and antiangiogenesis effects under 1064-nm laser irradiation at a power density lower than the skin tolerance threshold value.</p> ER -